Dhea Science

How DHEA works in the female body: the steroidogenesis pathway, receptor interactions, cell signaling, and bone health considerations.

Where DHEA is made, the enzymes that convert it into androgens and estrogens, and what that pathway means during midlife and menopause.

How DHEA converts into testosterone and estrogen inside target tissues, and why that intracrine step matters for women in midlife.

Bone loss accelerates after menopause. Here is what DHEA trials have found for bone density, and how strong that evidence actually is.

DHEA and cortisol both come from the adrenal glands. Here is what research says about how they relate and why the ratio gets attention.

How DHEA may interact with immune function, the proposed mechanisms, and what the research supports for women in midlife.

How DHEA converts to estrogen and testosterone during perimenopause, why that conversion varies, and what it means for hormone balance.

How perimenopausal hormone shifts may touch gut health, and what the limited DHEA research can and cannot say about that connection.

Early research on DHEA and the gut microbiome, what the hormone-microbiome link may involve, and what the studies do not yet show.

What DHEA supplementation has actually been shown to do, separating the FDA-approved vaginal use from the weaker evidence for oral doses.

What the adrenal glands do, how DHEA production changes over a lifetime, its role as a precursor, and where adrenal insufficiency fits.