DHEA vs. HRT for Perimenopause: Understanding Differences and Potential Benefits
DHEA and HRT work differently on perimenopausal symptoms. Here is how they compare on mechanism, evidence and the trade-offs involved.
DHEA and HRT work differently on perimenopausal symptoms. Here is how they compare on mechanism, evidence and the trade-offs involved.
How to think about a DHEA starting dose in midlife, the ranges used in research, who should avoid it, and how to monitor and adjust.
What separates a reliable DHEA supplement from the rest: quality control, third-party testing, and how dose and formulation factor in.
Evidence for DHEA and perimenopausal mood swings and depression, covering the postmenopausal trials and what they do not settle.
How DHEA may interact with hormonal drugs, cytochrome P450 metabolism and mental health medications, and who should review it first.
What the evidence shows about DHEA and libido in perimenopause, covering sexual function outcomes and the side effects worth knowing.
Where DHEA is made, the enzymes that convert it into androgens and estrogens, and what that pathway means during midlife and menopause.
Prasterone is FDA-approved vaginal DHEA; over-the-counter DHEA is not. What separates them on evidence, regulation and intended use.
The DHEA doses actually used in clinical trials for women, covering vaginal prasterone, oral supplements, fertility and metabolic studies.
What research says about DHEA and bone density during perimenopause, including where the evidence is strong and where it stays uncertain.
How DHEA and thyroid hormones may interact during perimenopause, what the research supports, and what remains unclear for midlife women.
A look at DHEA and skin aging, covering how skin changes in midlife, what studies report on skin appearance, and the current limits.